Abstract
The effects of forskolin and cholera toxin on the regulation of cAMP release were studied in a neurotensin-secreting rat C-cell line. The interaction of these agents with norepinephrine, a potent neurotensin secretagogue, was also investigated. Forskolin stimulated cAMP release 10 2–10 3 fold while it increased neurotensin release 2–3 fold. Cholera toxin caused a 10 2–10 3 fold increase in cAMP release and had no effect on neurotensin release. We conclude that the 44–2 C-cells provide a new model for studying the regulation of the concomitant (via forskolin) or independent (via cholera toxin) secretion of cyclic AMP and/or neurotensin.
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