Abstract
Corticosterone levels in rats with lesions of the fornix and operated controls were examined under a variety of stimulus conditions. Fornix-lesioned rats did not differ from controls in the basal, nonstimulated condition and showed normal corticosterone increases to food deprivation. The lesioned rats failed to show normal corticosterone elevations during extinction of an operant response and to handling and transport to a new environment. The lesioned rats also showed greater than normal reduction in corticosterone levels during continuous reinforcement of an operant response and during a short eating session in the home cage. The results suggest that some events that influence corticosterone levels are mediated by neural circuits that involve the hippocampus, and others are not. It is suggested that events with effects mediated by the hippocampus relate to the development and/or violation of expectancies about motivationally significant stimuli.
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