Effects of fluticasone propionate combined with budesonide on intercellular adhesion molecule-1, plasma substance P concentration and salivation immunoglobulin A in children with bronchial asthma

Abstract

Objective To investigate the effects of fluticasone propionate combined with budesonide on intercellular adhesion molecule-1(ICAM-1), plasma substance P(SP)concentration and salivary immunoglobulin A(sIgA)in children with bronchial asthma. Methods A retrospective study was performed 82 cases of child patients with bronchial asthma who were admitted from July 20 to July 2019.There were 43 males and 39 females, aged(6.52±2.36)years, ranging from 3 to 11 years.According to the computer digital table method randomly divided into two groups, 41 cases in each group.The control group was treated with budesonide.The experimental group was treated with fluticasone propionate combined with budesonide.The efficacy and ICAM-1, SP concentration and salivary sIgA were compared between the two groups. Results After treatment, ICAM-1[(218.25±2.13)μg/L], SP concentration[(41.44±2.21)μg/L]in the combined treatment group was lower than that in the monotherapy group[(234.65±2.18)μg/L, (49.73±2.26)μg/L]and saliva sIgA[(17.39±1.12)μg/L], FVC[(3.53±0.25)L], FEV1[(2.72±0.23)L]in the combination treatment group was higher than that in the monotherapy group[(13.56±1.23)μg/L, (2.61±0.32)L, 2.24±0.35)L], and the difference was statistically significant(P 0.05). Conclusion Fluticasone propionate combined with budesonide in the treatment of children with bronchial asthma can effectively reduce the concentration of ICAM-1 and SP, increase the level of saliva sIgA, improve the lung function of children without increasing adverse drug reactions. Key words: Fluticasone propionate; Budesonide; Bronchial asthma in children; Intercellular adhesion molecule-1; Substance P; Secretory immunoglobulin A