Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

Andrii Demkovych,Vitaliy Shcherba,Olha Yaremchuk,Halyna Stoikevych,Volodymyr Machogan,Vitalii Luchynskyi

doi:10.3897/pharmacia.68.e67341

Abstract

The article presents the results of study effect of quercetin on the indicators of endogenous intoxication syndrome under conditions of experimental periodontitis. One of the key links in the pathogenesis of any inflammatory disease, including maxillofacial area, is endogenous intoxication, an important pathophysiological mechanism of which is the activation of lipid peroxidation. The experimental animals were treated by intramuscular injections with water-soluble quercetin for 7 days. For further research the blood serum was selected in which was determined the content of middle molecular weight molecules and erythrocyte intoxication index. Excessive lipoperoxidation was accompanied by accumulation of peroxidation products and depletion of antioxidant reserves, which led to accumulation of toxic substances. That is why the study of the level of middle molecular weight molecules and erythrocyte intoxication index in simulated bacterial-immune periodontitis is a reliable criterion. Quercetin was able to reduce the expression of endogenous intoxication syndrome in experimental bacterial-immune periodontitis.

Highlights

The periodontal complex is the tissue that surrounds the tooth and ensures its stable position relative to the alveolar hole
Middle molecular weight molecules belong to the hydrophilic components of endogenous intoxication
They are formed due to increased proteolysis and have an alternative effect on the body due to high functional activity (Vining et al 2019). As it can be seen from the table, the content of middle molecular weight molecules, which has been determined at a wavelength of 254 nm in the serum, has increased on the 14th day – by 1.28 times (p < 0.01) compared with the intact group

Summary

Introduction

The periodontal complex is the tissue that surrounds the tooth and ensures its stable position relative to the alveolar hole. It consists of gums, periodontal ligament, root cementum, bone tissue of alveolar processes. Periodontal disease affects either any of these components, or the entire periodontium. The connection between the teeth and gums weakens, and the alveolar processes of the jaw bones are destroyed. Chronic periodontitis can occur in the background of periodontal pathogenic microflora, which is present in plaque. These microorganisms produce toxins that are detrimental to the gum epithelium.

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Conclusion