Abstract
The effects of saturated fatty acids of different chain length on polymorphonuclear leukocytes were studied to better understand the relation between hydrophobic binding to cell surface and respiratory stimulation induced by anionic surfactants. Some fatty acid anions with long alkyl chain length bind tightly to the leukocyte membrane, leading to a striking stimulation of the oxidative metabolism similar to that occuring during phagocytosis, i.e. increase of cyanide-insensitive oxygen uptake and of glucose oxidation through the hexose monophosphate pathway. Unsaturated fatty acids are more effective in the stimulation of leukocyte respiration than saturated fatty acids, but the stimulation is transient, rapidly decaying with time. The effects of fatty acids are discussed.
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