Effects of exposure of chlorpyrifos-ethyl on metabolism and oxidative damage in rats and their offspring

Abstract

Chlorpyrifos-ethyl (CE) is one of the most widely used organophosphorus insecticides for industrial, agricultural and public health purposes. The aim of the study was to evaluate the effect of CE exposure via gavage on metabolic and redox status in pregnant, lactating rats and their pups at weaning. The oral administration of this pesticide at doses of 1 mg/kg of body weight No Observed Adverse Effects Level (NOAEL), 5.4mg/kg b.wt (1/25LD50) and 13.5 mg/kg b.wt (1/10LD50) was given 1day/2 to female rats during the entire gestation and lactation period. Plasma biochemical parameters as well as lipid profiles and oxidative stress markers were determined. Oral CE exposure induced an increase in plasma glucose, urea, creatinine and lipid status levels in mothers at parturition (day 0) and at the end of lactation (day21) and in their offspring at weaning (day21). An altered oxidant/antioxidant status marked in mothers treated by the insecticide at day 0 and day 21 and these disturbances were also seen in their offspring. In conclusion, different doses CE exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to offspring metabolic changes. CE should be used with caution especially during pregnancy and lactation period.