Effects of Excess Arginine on Swine Growth and Plasma Amino Acid Levels

Abstract

One hundred seventy-six crossbred weaned pigs (4 to 5 wk old) were used in two growth trials to determine the effect of excess arginine on pig growth and plasma amino acid levels. In the first 28-d growth trial, two lysine levels (1.03 and 1.26%) and three arginine levels (.94, 1.29 and 1.63%) were used in a nested treatment arrangement. Lysine supplementation improved daily gains (P less than .05), tended to improve feed efficiency (P less than .12) and caused a general reduction in plasma essential amino acid levels. Arginine had no effect on daily gain or feed intake, but pigs fed 1.03% lysine and 1.63% arginine had reduced gain/feed (P less than .05). Arginine did not affect gain/feed of pigs fed 1.26% lysine. Plasma lysine levels were reduced (P less than .06) by excess arginine in pigs fed 1.26% lysine, but not in pigs fed 1.03% lysine. The four treatments for the second 26-d growth trial consisted of three diets containing .92% lysine and either .72, 1.10 or 1.61% arginine and a positive lysine control (1.10% lysine, .72% arginine). Lysine was the limiting amino acid in the basal diet, but arginine had no effect on daily gain, daily feed intake, gain/feed or plasma lysine levels. Plasma threonine and methionine levels were reduced by excess arginine in both experiments, while the other plasma essential amino acid levels were not affected by dietary arginine. Conclusions are that large excesses of added arginine may affect lysine utilization, but pig performance was affected only when excess arginine was combined with a lysine deficiency. The arginine levels similar to those found in grain-soybean meal swine diets had no effect on pig performance in these experiments.