Abstract
The hypothesis that prolactin can antagonize the suppressive effects of estrogen on food intake and body weight was tested. In the first experiment, ovariectomized virgin females were injected with either estradiol benzoate (EB), EB and prolactin, or oil. Oil-injected animals gained significantly more weight than did the two EB-injected groups. Oil-treated animals and animals receiving both EB and prolactin ate more than animals injected with EB alone. In the second experiment, ovariectomized and sham-operated animals were injected with either prolactin or saline. Both ovariectomized groups gained weight as did the intact females injected with prolactin. Differences among these groups were not significant. These studies suggest that, while exogenous prolactin has weight enhancing properties in the intact animal, in ovariectomized and estrogen treated animals, prolactin effects are not present.
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