Abstract
Electrospinning is a perspective method widely suggested for use in bioengineering applications, but the variability in currently available data and equipment necessitates additional research to ascertain the desirable methodology. In this study, we aimed to describe the effects of electrospinning technique alterations on the structural and mechanical properties of (1,7)-polyoxepan-2-one (poly-ε-caprolactone, PCL) scaffolds, such as circumferential and longitudinal stress/strain curves, in comparison with corresponding properties of fresh rat aorta samples. Scaffolds manufactured under different electrospinning modes were analyzed and evaluated using scanning electronic microscopy as well as uniaxial longitudinal and circumferential tensile tests. Fiber diameter was shown to be the most crucial characteristic of the scaffold, correlating with its mechanical properties.
Highlights
One of the most significant advantages of electrospun scaffolds is the resemblance between the natural extracellular matrix (ECM) and the nanofibers [2], which are much smaller in diameter than the adhering cells, implying the formation of a suitable microenvironment for cell repopulation [3,4,5]
We confirmed the parameters that are crucial for the electrospinning process and described their significance
The pore size can be increased by increasing the polymer solution concentration, increasing the spinneret motion, and decreasing the collector rotation speed
Summary
Polymers 2022, 14, Currently, electrospinning is one of the most popular methods in constructing tissueengineered vessels, and over nine thousand articles have been dedicated to this sphere of graft production This method is highly applicable to tissue construction because of its variability: the availability of a large number of polymers and techniques to choose from allows researchers to obtain the desirable composition, size, and architecture of the resultant fibers by regulating specific parameters. One of the most significant advantages of electrospun scaffolds is the resemblance between the natural extracellular matrix (ECM) and the nanofibers [2], which are much smaller in diameter than the adhering cells, implying the formation of a suitable microenvironment for cell repopulation [3,4,5]. All of these features result in an immunologically neutral temporary implant that functions as a host site for autologous cells and a growth factor-containing system, which will be replaced, in advance, by functionally sustainable autologous tissues
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