Abstract
EEG activity was recorded in rats submitted to osmotic opening of the BBB by intracarotid mannitol infusion. This procedure produced an immediate short-lasting depression of the EEG and a tardive paroxysmal EEG activity. Both these phenomena were more relevant on the ipsilateral hemisphere. In some instances a tonico-clonic seizure was recorded. Pre-treatment with diazepam abolished the occurrence of the tardive EEG and behavioral modifications. In accord with previous findings, focal seizure activity is likely to be responsible for the metabolic abnormalities associated with osmotic opening of the BBB. This preparation therefore produces in the brain unphysiological states in respect to local metabolism and electrical function.
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