Effects of different glucose metabolic status on the occurrence and severity of breast cancer: a preliminary study

Abstract

Objective To investigate the effect of different glucose metabolic statuses on the occurrence and severity of breast cancer. Methods A total of 131 hospitalized female patients with breast cancer from April 2012 to April 2014 were enrolled as breast cancer group, 72 healthy women without breast diseases as the control group. All the subjects without a history of diabetes in the two groups underwent an oral glucose tolerance test (OGTT). Based on the OGTT results the patients were divided into three groups: normal glucose tolerance (NGT group), impaired glucose regulation (IGR group), and diabetes mellitus (DM group). The information of the subjects were collected including age, menopausal status, body mass index (BMI), blood pressure, sugar metabolism, liver and kidney function, blood lipid indicators, and pathology results of breast cancer group. Binary Logistic regression model was used to analyze the OR value of the associated risk factors of breast cancer. Results (1) Compared with the control group, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting plasma glucose (FPG), fasting insulin (FINS), and insulin resistance index (HOMA- IR) in breast cancer group were significantly higher, and all the differences were statistically significant (t=2.17- 3.34, P 0.05). (3) Logistic regression analysis showed that adjusted by age, BMI, blood pressure and blood lipids, IGR and DM were independently associated with risk of breast cancer (OR=4.357, 2.778, respectively, P 0.05). Conclusion Glucose regulation status has a significantly independent effect on the incidence of breast cancer. In breast cancer risk prediction, the effect of impaired glucose regulation is even greater than that of diabetes. Key words: Impaired glucose regulation; Diabetes; Breast cancer