Effects of different doses of propofol on hepatic and renal function in morbid obese patients undertook bariatric surgery

Abstract

Objective To compare the effects of propofol anesthesia on liver and kidney function after weight-loss surgery within two different dose. Methods 23 ASA class I or II morbid obese patients (BMI≥35 kg/m2) undergoing bariatric surgery will be randomly divided into total body weight grope (group I involved 11 cases) and lean body weight group (group II involved 12 cases) . Another 6 ASA I- II normal weight patients (BMI of 18.5-24 kg/m2) undergoing laparoscopic surgery were enrolled for contrast (group III) . They received defferent dose propofol for anesthesia. Renal and hepatic functions were detected before and on the 6h (T1), 24h (T2), and 72h (T3) after withdrawal propofol, such as serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), urea nitrogen (BUN) and β2-microglobulin (β2-MG) and so on. Results There were no significant differences in liver function indexes such as AST and ALT at different time point in three groups. Compared with T1, ALB and BUN in the three groups of patients was significantly decrease in T3 and T4 (P<0.05); Compared with T1, B2-microglobulin in the three groups decreased significantly in T2-T3 (P<0.05). Conclusions For morbidly obese patients, two different doses of propofol anesthesia have no significant effect on liver and kidney function in morbidly obese patients. To reduce the complications of propofol infusion syndrome, LBW is recommended as the dose of propofol. Key words: Propofol; Obesity; Drug dosage; Hepatic and renal function; General anesthesia