Abstract
Objective : Cardiopulmonary bypass (CPB) triggers systemic inflammation. Inflammatory system activation may cause deteoriation in liver and renal functions. In our study we aimed to search the effect of on-pump CPB and beating heart off-pump coronary artery bypass grafting (CABG) surgery techniques on renal and liver functions. Methods: Sixty four patients who underwent coronary artery surgery were included in the study and were divided into two groups: on-pump CPB group (40) and beating heart off-pump CABG group (24), prospectively. The blood samples were collected for preoperative and postoperative levels of blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and AST to ALT ratio at 24 th and 48 th hours. Results: Clinical and demographic features were similar in both groups. There were no statistically significant difference in levels of preoperative BUN, creatinine, AST, ALT, AST to ALT ratio. The postoperative 24 th hour plasma levels of creatinine, AST and AST/ALT were lower in beating heart off-pump CABG group but BUN and ALT levels were similar among the two groups. The postoperative 48 th hour plasma levels of BUN, creatinine, AST and AST/ALT were lower in beating heart off-pump CABG group but levels of ALT were similar in both groups. Conclusion: Based on our findings we conclude that beating heart off-pump CABG has lower negative effect on liver and renal function than on-pump CPB. Abstract of this manuscript was presented in 7th Congress of Update in Cardiology and Cardiovascular Surgery in association with TCT Mediterranean as a poster.
Highlights
Cardiac surgery has progressed much in the last forty years
We aim to investigate the effects of off-pump and on-pump coronary artery bypass grafting (CABG) procedures on renal and liver functions
The postoperative 24 th hour plasma levels of creatinine, AST and AST/ALT ratio were lower in offpump group but blood urea nitrogen (BUN) and ALT levels were similar between the two groups
Summary
Cardiac surgery has progressed much in the last forty years. Inflammatory system activation triggered by cardiopulmonary bypass (CPB) may lead to a variety of complications including respiratory insufficiency, lung damage, cognitive dysfunction and brain damage [1,2,3]. Off-pump CABG procedure has been being performed more frequently without the need of CPB. The principal goal is to avoid the negative effects of cardiopulmonary bypass on physiological systems [4,5,6]. CPB induced systemic inflammation activation may cause deteoriation in liver and renal functions contrubuting to increased morbidity and mortality [3,4,5]. We aim to investigate the effects of off-pump and on-pump CABG procedures on renal and liver functions
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