Abstract
ABSTRACT The objectives of this study were to investigate the effects of tributyrin (TB) and coated sodium butyrate (CSB) on intestinal morphology, disaccharidase activity and intramuscular fat of broilers challenged with lipopolysaccharide (LPS). A total of 160 1-day-old healthy Cobb broilers were randomly allocated into four groups: (1) control; (2) LPS, in which broilers were fed a basal diet and intraperitoneally injected with 500 μg/kg LPS on days 38, 40 and 42; (3) TB, in which LPS-challenged broilers were fed basal diet supplemented with 500 mg/kg TB; and (4) CSB, in which LPS-challenged broilers were fed basal diet supplemented with 877 mg/kg CSB. Addition of TB and CSB inhibited (p<0.05) the decrease in villus height in the duodenum and ileum of LPS-challenged broilers, respectively. Both TB and CSB increased (p<0.05) activity of maltase in the small intestine, and TB increased (p<0.05) activity of isomaltase in the ileum. Additionally, dietary addition of TB and CSB decreased (p<0.05) the content of intramuscular fat. In conclusion, dietary supplementation of TB was more effective than CSB in improving intestinal morphology and disaccharidase activity of LPS-challenged broilers, and they both reduced intramuscular fat in the breast and legs.
Highlights
Broilers are raised under modern farming conditions characterized as large scale and high intensity stocking, and suffer from considerable stress, with sensitivity to different types of stressor (Yalcin et al, 2001)
Dietary supplementation of TB was more effective than coated sodium butyrate (CSB) in improving intestinal morphology and disaccharidase activity of LPS-challenged broilers, and they both reduced intramuscular fat in the breast and legs
The objective of the present study was to investigate the effects of dietary supplementation of TB and CSB on intestinal morphology, disaccharidase activity, and intramuscular fat of LPS-challenged broilers
Summary
Broilers are raised under modern farming conditions characterized as large scale and high intensity stocking, and suffer from considerable stress, with sensitivity to different types of stressor (Yalcin et al, 2001). Some feed additive is required to reduce stress from high-intensity stocking, and to increase production performance in broilers. Other studies have shown that dietary butyrate supplementation improves growth performance, enhances immune function (Jang et al, 2017; Bedford & Gong, 2017), reduces production of pro-inflammatory cytokine such as interleukin (IL)-1β and IL-6 (Li et al, 2015), modulates intestinal microbiota (Yang et al, 2018) and promotes intestinal development (Mazzoni et al, 2008; Zhang et al, 2011). Butyrate is hardly used in animal production due to the fact that it is volatile and strong smelling, and quickly absorbed in the upper part of the digestive tract
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