Abstract
This study was undertaken with growing rats to compare the effects of dietary 0.1% myo-inositol or 0.5% sodium phytate on the changes in the metabolism of hepatic lipids due to sucrose feeding. Liver weight, hepatic concentrations of total lipids and triglyceride, and hepatic activities of glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49), malic enzyme (ME, EC 1.1.1.40), fatty acid synthetase (FAS, EC 2.3.1.85), citrate cleavage enzyme (CCE, EC 4.1.3.8) and acetyl-CoA carboxylase (CBX, EC 6.4.1.2) were remarkably higher in rats fed on sucrose than in rats fed on corn starch for 12 or 13 days. Dietary myo-inositol and phytate significantly depressed the rises in liver weight, hepatic concentrations of total lipids and triglyceride, and hepatic activities of G6PD, ME, FAS and CCE due to sucrose feeding. These results suggested that dietary myo-inositol and phytate both can protect sucrose-fed animals against an accumulation of hepatic lipids, which might be at least in part ascribed to the depression in the hepatic lipogenesis.
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