Effect of dietary phytic acid on hepatic activities of lipogenic and drug-metabolizing enzymes in rats fed 1,1,1-trichloro-2,2-bis (P-chlorophenyl) ethane (DDT)

Abstract

This study was conducted to examine the influence of dietary sodium phytate (10.2g/kg diet) on hepatic activities of lipogenic and drug-metabolizing enzymes in rats fed 1,1,1-trichloro-2,2-bis (P-chlorophenyl) ethane (DDT) (0.7g/kg diet). Dietary DDT enhanced hepatic lipids, elevated hepatic activities of lipogenic enzymes, increased serum levels of cholesterol and phospholipid, and raised hepatic activities of drug-metabolizing enzymes. Dietary phytate significantly decreased the rises in hepatic lipids and the activities of lipogenic enzymes due to DDT feeding. The enhancement in hepatic activity of phase II drug-metabolizing enzyme, glutathione S-transferase, that had been caused by DDT feeding was significantly enhanced with dietary phytate. These results suggest that dietary phytate can protect DDT-fed animals against an accumulation of hepatic lipids, by depressing of hepatic lipogenesis. The present study also implies that dietary phytate might improve the function of drug-metabolizing enzymes exposed to DDT.