Abstract
On the basis of the known inhibitory activity of diazoacetyl-glycine amide (DGA) on DNA and purine nucleotide synthesis, a series of experiments was performed to study, in greater detail, the effects of the drug on purine nucleotide metabolism. DGA produces a marked inhibition of de novo utilization of glycine and formate and a less pronounced inhibition in the “salvage” utilization of hypoxanthine for IMP synthesis. The synthesis of adenine and guanine nucleotides from hypoxanthine is also depressed by DGA, and the drug also causes unbalance in the ratio of the concentration of adenine and guanine nucleotides and a drop in the energy status of nucleotides. These findings and those already reported are related to a rather unspecific interaction of the drug with cellular components.
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