Effects of depressive symptoms on osteoporotic bone metabolism and prognosis of joint replacement surgery in elderly male patients with femoral neck fractures.

Abstract

To investigate the effect of depressive symptoms on osteoporotic bone metabolism and prognosis of joint replacement surgery in elderly male patients with femoral neck fractures. 102 elderly male patients with femoral neck fractures hospitalized in the Beijing Hospital from January 2017 to January 2019 were included. The patients with femoral neck fractures were divided into the depression group and the control group. The observation indicators included: bone mineral density, serum alkaline phosphatase, serum calcium, serum phosphorus, 25-hydroxy-vitamin D, osteocalcin, Type I procollagen amino-terminal propeptide, serum β-isomer of C-terminal telopeptide of type I collagen, hip function scores, and pain visual analogue scale at pre- and post-operative examinations. The BMD was significantly lower in the depressed group than in the control group [either for lumbar spine or hip, P<0.05]. Serum 25-(OH)-D levels and serum OC levels were lower (both P<0.05) in the depression group, while serum -CTX levels were higher in the depression group than in the control group (P<0.05). Depression severity (GDS score) was negatively correlated with BMD (r=-0.456, P<0.05), 25(OH)D (r=-0.546, P<0.05), and OC (r=-0.215, P<0.05), while positively correlated with β-CTX (r=0.372, P<0.05). The Harris scores of the depression group were lower than the control group (P<0.001). In the control group, VAS scores decrease at 12 months postoperatively while in the depressed group, VAS scores increased (P<0.001). Depression is a risk factor for low bone mineral density and fracture, and adversely affects functional recovery and pain relief after artificial femoral head replacement. Special care should be taken for those patients with depressive symptoms in orthopedic practice.