Abstract
Simple SummaryDecabrominated diphenyl ether (BDE-209) has been widely used in recent decades, and its cumulative toxicity to crops, animals and human beings is attracting increasing attention. In this study, we established broiler models to investigate the effects of BDE-209 exposure at doses of 0, 0.02, 0.4 and 4 mg/kg on growth, carcass traits, meat quality, blood profiles and antioxidant capacity. Our results suggested that BDE-209 exposure altered the blood profiles and carcass traits and exhibited toxicity in liver and kidney functions. Furthermore, BDE-209 increased plasma malondialdehyde (MDA) concentrations and decreased the activities of glutathione peroxidase (GSH-px) and superoxide dismutase (SOD), which implied aggravating oxidant stress and decline of antioxidant capacity in broilers.Decabrominated diphenyl ether (BDE-209) is widely used as a flame retardant and is detected at high levels in the environment. Its toxicities have been reported and have attracted attention. In the present study, broilers were used to determine the response in growth performance, carcass traits, meat quality, blood profiles and antioxidant system to BDE-209 exposure at doses of 0, 0.02, 0.4 and 4 mg/kg. The results showed that BDE-209 exposure at levels of 0.02 or 0.4 mg/kg increased feed intake and decreased feed efficiency. BDE-209 altered the blood profiles, such as reducing the numbers of white blood cells, lymphocytes and neutrophilic granulocytes. As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9–159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions. Moreover, BDE-209 exposure significantly increased plasma malondialdehyde (MDA) concentrations and decreased the activities of glutathione peroxidase (GSH-px) and superoxide dismutase (SOD), which implied aggravating oxidant stress and decline of antioxidant capacity in broilers. In conclusion, our data demonstrated that the environmental pollutant BDE-209 adversely influenced growth performance, increased the deposition of abdominal fat, impaired antioxidant capacity and the immune system and had potential toxicity to the liver and kidney of broilers.
Highlights
Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants (POPs) that are widely used as flame retardants in textiles, electronic appliances, construction materials
The occurrence of PBDEs is ubiquitous in various foods, animal feeds and raw materials, such as fish meal, soybean, rapeseed [2]
A dose-independent decrease in average daily gain was detected, there was no significant difference in Average daily gain (ADG) between the control and BDE-209-treated groups (Figure 1A, p > 0.05)
Summary
Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants (POPs) that are widely used as flame retardants in textiles, electronic appliances, construction materials. Their release, migration and accumulation in the environment during manufacture and usage contribute to the ubiquity of PBDEs. Around electronic waste recycling sites, contaminant PBDEs have been detected at high levels in the environment [1], feeds [2], fish [3], chicken [4], etc. The occurrence of PBDEs is ubiquitous in various foods, animal feeds and raw materials, such as fish meal, soybean, rapeseed [2]. The concentrations of PBDEs vary greatly, in different foods and animal feeds and in different countries and regions. The total concentrations of 17 measured PBDE congeners ranged from 0.02 to
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