Abstract
Experiments were performed on decerebrate cats to determine whether CBZ acted as a general depressant to spinal cord neurones or whether the depression was selective to certain groups of neurones. At doses which appreciably affected motoneurone pools, CBZ had no depressant effect on Renshaw or IA inhibition; most spontaneously active neurones in Rexed layers V and VI, and brainstem reticular formation cells were depressed by CBZ. These results indicate that CBZ does not have a general depressant action on spinal cord neurones. Although some direct action on the spinal cord may be present, the major effects are secondary to an apparent action on specific neurones in the brainstem.
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