Abstract
The purpose of the present study was to investigate the effects of curcumin on physical fatigue and oxidative damage induced by forced swimming exercise in mice. The mice were divided into quiet group and exercise group, and then the above two groups were divided into control group and medication group. The medication group received curcumin (100 mg/kg), while the control group received physiological saline for 28 days. The exercise group performed swimming exercise for 4 weeks and then performed exhaustive exercise. Exhaustive swimming time and superoxide dismutase (SOD) and malondialdehyde (MDA) contents in liver, as well as serum alanine aminotransferase (ALT) contents were measured. The data showed that curcumin could extend exhaustive swimming times of the mice, as well as increase the SOD contents in liver, while decreasing MDA contents in liver and ALT contents in serum. This study indicated that curcumin has anti-fatigue and protective effects against exercise induced oxidative damage.
Highlights
Curcuma longa L. is a perennial herb of the Zingiberaceae family
All other chemicals and reagents used in this study were of analytical grade and were obtained from Fuchen Chemical Reagent Co., Ltd. (Xi'an, China)
The mice were housed in an airconditioned specific pathogen-free grade level animal room with free access to standard laboratory diet and water ad libitum
Summary
Curcuma longa L. is a perennial herb of the Zingiberaceae family. Curcuma longa L. is widely distributed in some countries in East Asia, South Asia and Southeast Asia. In. China, Curcuma longa L. is widely cultivated in Taiwan, Fujian, Guangdong, Guangxi, Yunnan, Tibet and other places [2]. The dried rhizome of Curcuma longa L. is called "Jianghuang", which is a commonly used traditional Chinese medicine, and has been included in the Pharmacopoeia of the People's Republic of China. The chemical components of the rhizome of curcuma longa L. mainly include curcumin, demethoxycurcumin, bisdemethoxycurcumin, dihydrocurcumin, volatile oil, sugar and sterol [4]. Curcumin is a polyphenol compound, which is the main active component of curcuma longa L., and the content in its rhizome is 0.2%
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