Abstract
The purpose of this study was to examine the effects of Curculigo orchioides total glucosides in mouse perimenopause model. The castrated mice were treated with different doses of soybean isoflavone soft capsule, Gengnianan, C. rhizome total glycoside. Hypothalamus, thymus, spleen and uterus were collected and then fixed in 10% formaldehyde, HE staining, to observe the pathological changes of morphology. The results indicate that compared with the model group, soybean isoflavone soft capsule, gengnianan capsule and big, medium, small dose of C. rhizome total glycoside group could significantly improved the pathological changes in mouse uterus, hypothalamic, thickening of the thymic cortex and significantly increased the number of lymphocytes in the cortex, increased the volume of splenic nodule (p<0.01), in which the effect of large dose of C. orchioides total glycosides group was the best. In conclusion, C. orchioides total glucosides in mice caused by perimenopausal pathological changes of uterine, hypothalamus, spleen and other organs have good improvement effect.
Highlights
Perimenopausal syndrome is a clinical common disease
Perimenopausal syndrome have no separate records in Traditional Chinese Medicine (TCM)
Curculigo rhizome total glycoside was provided by the Henan University of Traditional Chinese Medicine chemistry room
Summary
Its incidence is increasing year by year (Su et al, 2014). Western medicine thinks women ovarian secretion of estrogen levels are closely related with the occurrence of perimenopausal syndrome, follicle stimuliting hormone increased and estradiol decreased leading to other system changes, resulting in a series of diseases (Qi, 2014). Perimenopausal women with cardiovascular disease incidence increased significantly (Weng, 2013) and there is significant correlation with the levels of estradiol (Zhu et al, 2015). Perimenopausal syndrome have no separate records in Traditional Chinese Medicine (TCM). The modern Chinese Medicine called it as menopausal syndromes (Ge et al, 2015; Li et al, 2014)
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