Effects of COX-2 Inhibitors, a New Class of Anti-Inflammatory Drugs, on Kidney Function in Older Patients

Abstract

Summaries for Patients4 July 2000Effects of COX-2 Inhibitors, a New Class of Anti-Inflammatory Drugs, on Kidney Function in Older PatientsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00023 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful in treating many painful conditions, including headaches and arthritis. Unfortunately, NSAIDs occasionally produce serious side effects, including stomach ulcers and kidney problems, particularly in older persons. A new type of NSAID, called cyclooxygenase-2 (COX-2) inhibitors, affects some important body processes less than do earlier NSAIDs (COX-1/COX-2 inhibitors). This suggests that COX-2 inhibitors (for example, rofecoxib) may cause fewer side effects in patients than COX-1/COX-2 inhibitors (for example, ibuprofen and indomethacin). However, some studies in animals suggest that COX-2 inhibitors also can cause ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet. A Randomized, Controlled Trial.” It is in the 4 July 2000 issue of Annals of Internal Medicine (volume 133, pages 1-9). The authors are S.K. Swan, D.W. Rudy, K.C. Lasseter, C.F. Ryan, K.L. Buechel, L.J. Lambrecht, M.B. Pinto, S.C. Dilzer, O. Obrda, K.J. Sundblad, C.P. Gumbs, D.L. Ebel, H. Quan, P.J. Larson, J.I. Schwartz, T.A. Musliner, B.J. Gertz, D.C. Brater, and S.-L. Yao.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet Suzanne K. Swan , David W. Rudy , Kenneth C. Lasseter , Charles F. Ryan , Kristin L. Buechel , Laurence J. Lambrecht , Manuel B. Pinto , Stacy C. Dilzer , Olga Obrda , Kimberly J. Sundblad , Carol P. Gumbs , David L. Ebel , Hui Quan , Patrick J. Larson , Jules I. Schwartz , Thomas A. Musliner , Barry J. Gertz , D. Craig Brater , and Siu-Long Yao Metrics 4 July 2000Volume 133, Issue 1Page: 1KeywordsArthritisCyclooxygenase 2DietDrugsIbuprofenKidneysNSAIDsPatientsRenal failureSalts ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...