Abstract
The administration of cortisone (5 mg/day) to thiouracil-fed rats increased thyroid size, total protein, total RNA and the ratios of RNA/DNA and protein/DNA. Similarly, the incorporation of 3H-leucine into protein was greater than that of the thyroids of uninjected goitrogen-fed animals. In contrast, corticoid given to euthyroid rats decreased thyroid size, total protein, total RNA and the ratio of RNA/DNA. Correspondingly, the incorporation of 3H-leucine into thyroid protein was also decreased in euthyroid animals by cortisone administration. The thyroid gland pool of (free) essential amino acids was unchanged by thiouracil treatment with or without cortisone. However, the pool of (free) nonessential amino acids in the thyroid was doubled by thiouracil feeding whether or not cortisone was injected. In corticoid- treated euthyroid rats, pools of both (free) essential and (free) nonessential amino acids were reduced to half those of untreated animals. These results support the conclusion that cortisone aff...
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