Abstract
The effects of a single intramuscular injection of 5 mg of corticosterone on oxygen uptake by homogenates prepared from brain, heart, diaphragm, liver, kidney, and testis tissues, and the effects on P:O ratios in mitochondria isolated from brain, heart, and liver of the rat were studied. Corticosterone treatment increased oxygen uptake (0.001 < p < 0.01) by liver homogenates and increased ATP formation (0.02 < p < 0.05) and P:O ratios (0.001 < p < 0.01) in liver mitochondria oxidizing malate. Nonsignificant increases were observed in P:O ratios and ATP formation in brain (0.1 < p < 0.2) and heart (0.05 < p < 0.1) mitochondria. No effect was observed on ATP formation or P:O ratios using succinate as substrate in any of the tissues studied. It was concluded that corticosterone treatment enhanced oxidative metabolism in rat liver homogenates and increased ATP formation and P:O ratios in rat liver mitochondria using malate as substrate. The results indicate that corticosterone has an effect on mitochondrial respiration near the NAD ↔ flavo-protein portion of the electron-transport chain.
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