Abstract
Diabetic retinopathy (DR) is one of the common neuronal and microvascular complications of diabetes, and it is the key cause of blindness in the populations aged from 20 to 74.The pathogenesis of DR remains elusive, and the role of complement in DR has attracted intensive attentions in recent years.The dysregulation of complement factors and regulatory proteins could affect the fate and functions of pericytes, endothelial cells, neuronal cells and glia cells in retina, which may be novel targets for anti-DR therapy.Advances regarding the characteristics of complement in the eye, the relationship between complement dysfunction and DR, complement gene polymorphism in DR and recent therapy explorations targeting complement pathways were reviewed, so as to providing new clues for the related research in the future. Key words: Diabetic Retinopathy; Inflammation; Complement
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
