Effects of Comorbidities on the Profile of Volatile Organic Compounds in the Exhaled Breath of Lung Cancer Patients

Abstract

The diagnostics of lung cancer by exhaled breath is a promising field in medicine; however, many patients with lung cancer have other concomitant diseases that could impact the accuracy of diagnostic techniques. This work is devoted to a GC–MS study of possible effects of the most common comorbidities: chronic heart failure, hypertension, obesity, diabetes mellitus, and atherosclerosis on the composition of volatile organic compounds in the exhaled breath of patients with lung cancer. Components and their ratios, which were different in groups of patients with lung cancer and diverse concomitant diseases, were found.