Abstract
Effects of Common INSIG-2 and SCAP Gene Variants on Metabolic Parameters in Coronary Artery Disease
Highlights
The function of sterol regulator element binding proteins (SREBPs), important transcription factors in cholesterol synthesis, is associated to SREBP cleavage activating protein (SCAP), insulin induced gene product-1 (INSIG-1) and INSIG-2
INSIG proteins mediate the regulation of cholesterol synthesis by sterol dependently binding to SCAP and HMG-CoA reductase (DONG et al 2012)
HDL-cholesterol (HDL-C) values and smoking situations were compared between the coronary artery disease (CAD) patients and controls
Summary
The function of sterol regulator element binding proteins (SREBPs), important transcription factors in cholesterol synthesis, is associated to SREBP cleavage activating protein (SCAP), insulin induced gene product-1 (INSIG-1) and INSIG-2. The HMG-CoA reductase gene, plus over 20 other genes that encode enzymes regulating the cellular intake and synthesis of cholesterol and unsaturated fatty acids, are controlled by the transcription factor protein family named sterol regulator element binding proteins (SREBPs). These proteins are embedded in endoplasmic reticulum (ER) immediately after synthesis. INSIG proteins mediate the regulation of cholesterol synthesis by sterol dependently binding to SCAP and HMG-CoA reductase (DONG et al 2012)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
