Abstract
Dementia is a general term for loss of memory, language, problem-solving, and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's disease (AD) is the most common cause of dementia. Risk factors as age, genetics, environment, lifestyle, and metabolic disease. The etiology of AD remains not fully explained, but both genetic and environmental risk factors have been proposed to be involved. Microscopically, intraneuronal neurofibrillary tangles (NFTs) and extracellular senile plaques characterize the AD. The amyloid cascade hypothesis (ACH) suggests that the imbalance between the Amyloid-β generation and its clearance causes dysfunction and consequently cell death. Coconut oil may represent a cheap and natural treatment for AD. This is because coconut oil contains medium-chain triglycerides (MCTs), which are digested to ketones in the liver that are linked to mitochondrial function enhancement and oxidation-reduction. Recent studies have investigated the possibility of using trans-zeatin and phytoestrogen and other sex hormones like substances present in coconut water and a young coconut juice (YCJ) in reducing the chance of AD. Coconut is known as a 'functional food' that is extremely nutritious. Virgin coconut oil (VCO) differs from ordinary coconut oil as the former contains a lot more biologically active components. Phenolic compounds and hormones contained in coconut can help prevent amyloid b peptide aggregation, potentially inhibiting a key step in the pathogenesis of AD. Coconut can be useful in the treatment of obesity, dyslipidemia, elevated low-density lipoproteins, insulin resistance, and hypertension-these are the risk factors for chronic venous disease and type II diabetes, as well as for AD.
Highlights
It is estimated that the worldwide prevalence of Alzheimer's disease (AD) will triple by 2050 (Langa, 2015)
The gradual accumulation of the pathology of cerebral extracellular AD known as amyloid, which is mostly composed of aggregated amyloid-b (Ab) peptides, as well as the accumulation of intracellular neurofibrillary tangles, appears to start up to 17–20 years before a clinically observable disease (Villain et al, 2012)
Recent literature has suggested that the use of coconut oil (CO), coconut water, and coconut cream may have significant positive effects on the lowering of plasma cholesterol, blood pressure (BP) control, and blood glucose levels, all of which are risk factors associated with AD
Summary
It is estimated that the worldwide prevalence of AD will triple by 2050 (Langa, 2015). The World Alzheimer Report 2015 revealed that 46.8 million people worldwide were living with dementia in 2015, and the total global societal cost of dementia was estimated to be the US $818 billion. AD is an extremely debilitating condition currently falling within the top 10 causes of death across the world This causes a severe fiscal burden on health services since AD is an extremely financially costly neurological disease to manage (Nichols et al, 2019). The number of factors may increase or decrease an individual’s chances of developing the disease. These risk factors include age, genetics, environment, lifestyle, and metabolic diseases (Fernando et al, 2015). Tahani Ahmad Al-Matrafi/International Journal of Advanced and Applied Sciences, 8(5) 2021, Pages: 122-129
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of ADVANCED AND APPLIED SCIENCES
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
