Abstract
The need for better AD animal models.
Highlights
Edited by: Rafael Franco, University of Barcelona, Spain Reviewed by: George Perry, University of Texas at San Antonio, USA Rafael Franco, University of Barcelona, Spain
Even though some human brain aging aspects can be observed in aged non-human primates and perhaps in other mammalian species, they do not readily develop the full set of neuropathological and/or clinical phenotypic features observed in the human pathology
Cell and animal models, including genetically engineered non-mammalian species (C. elegans, D. melanogaster, zebra fish) have been remarkably useful in dissecting the basic disease mechanisms and for the screening of compounds directed toward specific molecular pathways involved in Alzheimer’s disease (AD)
Summary
Edited by: Rafael Franco, University of Barcelona, Spain Reviewed by: George Perry, University of Texas at San Antonio, USA Rafael Franco, University of Barcelona, Spain. A commentary on Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?
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