Effects of Clinical Pharmacist Intervention on the Use of Antibacterials During Perioperative Period of Cesarean Section

Abstract

Objective To evaluate the effects of clinical pharmacist intervention on the use of antibacterials during perioperative period of cesarean section. Methods The patients with cesarean section who were not receive clinical pharmacist intervention on the use of antibacterials during perioperative period from July to September 2012 in Shaanxi Martenal and Child Hospital were chosen into non-intervention group(n= 136). The patients with cesarean section who received clinical pharmacist intervention on the use of antibacterials during perioperative period from July to September 2013 in the same hospital were chosen into intervention group(n= 145). The rationality of prophylactic use of antibacterials during perioperative period and effects of hospitalization were compared, retrospectively. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Shaanxi Marternal and Child Hospital. Informed consent was obtained from each participating patient. The average age, operation duration and the amount of bleeding had no significant differences between two groups (P> 0.05). Results After the intervention of clinical pharmacist, the rationality of choice of medicine and medication time of the preventive application of antibacterials during perioperative period were statistically improved compared with those of non-intervention(χ2 = 6.30,221.38; P = 0.01,0.00). While the time points of prophylaxis use of antibacterials and mean hospital days had no significant differences between two groups(χ2/t= 1.36, 1.60; P=0.24,0.11). The per capita antibacterial expense, per capita total medicine expense and per capita total hospitalization expense were statistically lower after intervention (t = 28.99,5.10, 4.23; P = 0.00, 0.00, 0.00). Conclusions The rationality of use of antibacterials during perioperative period of cesarean section were significantly improved after clinical pharmacist intervention, which could reduce hospitalization expense. The clinical pharmacist intervention on the preventative application of antibacterials is feasible and effective. Key words: Perioperative period; Anti-bacterial agents; Pharmacists