Abstract
The optical and barrier properties of the corneal epithelium, which are essential for normal vision, depend on the maintenance of epithelial membrane integrity and tight junctional continuity between neighboring cells. Changes in tear film osmolality can occur in daily living (e.g., wind exposure, or swimming in fresh or salt water) and lead to alterations in epithelial cell volume that could affect epithelial topography and tight junction continuity. If these changes are uncompensated, they could compromise the corneal epithelial optical and barrier function. In some other cells, compensation includes reswelling to their isotonic volume through an appropriate regulatory volume increase (RVI). Frequently, this response is dependent on the activity of the bumetanide-sensitive, ouabaininsensitive Na-K-2Cl cotransporter.1
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