Effects of changes in the physical properties of the central elastic artery on haemodynamic characteristics during ageing

Abstract

The change in blood pressure during the ageing process depends on the changes in the physical properties of the arterial system. The conventional method of studying ageing, i.e. observing a focus group of people, requires long periods of time and also makes it difficult to separate the ageing effect from the effects of complex geriatric diseases. Therefore, a computer simulation was used to analyse how physical property changes in the central elastic artery during the ageing process affect the blood pressure and input impedance of the blood vessels. An increase in the arterial stiffness and an increase in the wall thickness increased the systolic pressure and the pulse pressure. An increase in the lumen diameter decreased the mean pressure. The pulse wave velocity and shape were changed in the central elastic artery group but were not changed outside this group. Also, the input impedance at a low frequency was increased in the central elastic artery group but was not changed outside this group. In this study, the way in which changes in specific physical properties of the artery affect the haemodynamic characteristics during ageing was analysed.