Abstract
Tumor-treating field (TTF) therapy has been receiving attention as a new minimally invasive treatment for cancer. In this treatment, an alternating electric field applied to target cells inhibits cell division by a dielectrophoretic force acting on chromosomes and microtubules. Previous studies have shown that an extremely weak electric field of only a few volts per centimeter interferes with chromosome migration and spindle formation. However, the therapeutic range of TTF treatment is still limited. To increase the efficacy of the treatment, the electric field to the target cells must be optimized. Therefore, the aim of this study was to investigate the effect of the electric field frequency, cell morphology, and electrical properties on the outcome of TTF treatment. Three-dimensional finite element models of a sphere and dividing cell were developed, and the distributions of the electric field and dielectrophoretic force were calculated.
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