Abstract
Background: Sarcopenia, is a major concern for our aged society because sarcopenia is a fundamental cause of frailty and functional disability. Aim: The effects of catechin-ingestionp and/or heat treatment on the volume in quadriceps muscles, isometric force of knee extension, and serum thiobarbituric acid reactive substances (TBARS) were investigated in healthy elderly women. Methods: Subjects (71.0 ± 0.7 years old, n=27) were divided into 3 groups; 1) catechin-ingested, 2) heatstressed, and 3) catechin-ingestion with heat stressed (catechin+heat) groups. Subjects in both catechin-ingested and catechin+heat groups daily ingested 350 ml of green tea containing 540 mg of catechin in one hour for 10 weeks. Heat stress was applied on the quadriceps muscles for 8 hours a day and 4 days a week by using two heat- and steam generating sheets. Results: In catechin+heat group, muscle volume (Pre: 670 ± 38.7 cm2, Post: 676 ± 37.2 cm2) and maximal isometric force (Pre: 25.8 ± 2.5 kg, Post: 27.0 ± 2.5 kg) were significantly increased by the 10-week of treatment (p<0.05), but not in catechin-ingested and heat-stressed groups. The time of Timed-Get-Up-and-Go test (TUG), which is widely used to measure sit-to-stand performance, in both catechin-ingested (Pre: 6.70 ± 0.33 s and Post: 6.19 ± 0.28 s) and catechin+heat (Pre: 6.49 ± 0.30 s and Post: 5.95 ± 0.24 s) groups in catechin-ingested group; was significantly shortened by the treatment (p<0.05). Following 10-week of the treatment, serum TBARS levels in both catechin ingested (Pre: 29.06 ± 1.32 nmol/ml, Post: 24.47 ± 2.30 nmol/ml) and catechin+heat (Pre: 29.84 ± 1.57 nmol/ml, Post: 23.92 ± 0.98 nmol/ml) groups were significantly decreased (p<0.05), but not in heat group. Conclusions: Evidences suggest that catechin-ingestion with heat stress might improve impaired muscle function of elderly women.
Highlights
Aging-related decline of muscle strength and mass, so-called sarcopenia, is a major concern for our aged society because sarcopenia is a fundamental cause of frailty and functional disability [1,2]
Reactive oxygen species (ROS) in skeletal muscle cells are suggested to induce an increase in proteolysis which leads to muscle atrophy [5,6]
We investigated the effects of catechin-ingestion and/or heat stress on skeletal muscle mass and strength in elderly women
Summary
Aging-related decline of muscle strength and mass, so-called sarcopenia, is a major concern for our aged society because sarcopenia is a fundamental cause of frailty and functional disability [1,2]. Reactive oxygen species (ROS) in skeletal muscle cells are suggested to induce an increase in proteolysis which leads to muscle atrophy [5,6]. Oxidative stress is proposed as one of major causes of sarcopenia [9]. If oxidative stress in skeletal muscle is increased by aging, supplementation of antioxidant could prevent the age-related loss of muscle mass and strength. Sarcopenia, is a major concern for our aged society because sarcopenia is a fundamental cause of frailty and functional disability
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