Abstract

Objective To study the effects of carbon disulfide(CS2) exposure and the combined effects with noise on rat myocardium tissue. Methods After CS2 or noise,or both exposure,superoxide dismutase(SOD) activity and malonaldehyde(MDA) content were measured,and morphological changes were observed under microscope. Results After CS2 exposure(189 mg/kg),SOD activity in the myocardium was decreased from (44.36±0.43)U/mg pro to (41.78±0.51)U/mg pro(P<0.01) and MDA content increased from (2.20±0.09)nmol/mg pro to (2.72±0.27)nmol/mg pro(P<0.05).The morphological observation showed that the blood vessels were swollen,some myocardial fibers were broken and cross striation disappeared.When CS2 combined with noise,the above changes were markedly aggravated,SOD activity and MDA content were (40.21±1.01)U/mg pro and (3.99±0.28)nmol/mg pro respectively(P<0.01). Conclusion CS2 may damage the myocardium tissue,through interfering the metabolism of free radicals and enhancing the lipoperoxidation.The combination of CS2 with noise exposure have synergic effects.

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