Abstract
Effects of carbohydrate (CHO) intake on the blood ethyl alcohol (ethanol) level were studied in rats with a surgically placed gastric cannula. A basal diet (protein, 2.07; fat, 1.98; CHO, 5.76 g/day), a high-CHO diet (CHO, 4.39 g/day) + ethanol, a medium-CHO diet (CHO, 2.69 g/day) + ethanol or a low-CHO diet (CHO, 0.98 g/day) + ethanol was infused into the stomach for 4 weeks starting from the 2nd postoperative week. The basal diet and the test diets were isocaloric, and the ethanol (2.80 g/day) in the test diets accounted for 39% of the total calories. The liquid diets (50 kcal in 50 ml) were infused over 16 h from 16.00 to 08.00 h each day. The low-CHO diet group had significantly higher blood ethanol levels than the high-CHO diet group 4, 8 and 16 h after the start of infusion. These groups could be ranked by liver triglyceride content at autopsy as follows: low-CHO > medium-CHO > high-CHO > or = basal. Consistent with the triglyceride content, histological changes of the liver could be ranked by the degree of fatty changes in the same order: low-CHO > medium-CHO > high-CHO > basal. Thus, for a given amount of ethanol consumption, lower CHO intake was associated with higher blood ethanol levels and with more severe fatty changes of the liver.
Published Version
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