Abstract
In the present paper, the ciliary activity and the fine structure of the pathological middle ear lining of rabbits induced by the exposure to 20 ppm SO2, 4 hours a day, 7 days/week for 4 consecutive weeks, were studied. In addition, carbocysteine, 200mg/kg, was given orally at different times during the experiment to 18 rabbits, and its effects on the middle ear lining were also studied.The following results were obtained;1) Otitis media with effusion including serous exudate in the tympanic cavity was produced by exposure to SO2. Such pathology was more remarkable 2 weeks after the completion of exposure than immediately after that.2) It was disclosed that the ciliary activity and the morphology of the middle ear lining was affected by the exposure to SO2. The affected ciliary activity and morphology of the middle ear lining remained for a considerably long period of time even after cessation of the exposure.3) Carbocysteine given either previously or concomitantly with SO2 exposure had a mild effects on the S02-induced middle ear mucosal disorder, however, it revealed significant effects on accerelating the repair of the middle ear lining.The conclusions were as follows;1) SO2 exposure may be one of the promising methods to elucidate the pathogenesis and pathology of the otitis media with effusion.2) Air polluting substance such as SO2 may be associated with an increase of the otitis media with effusion.3) Carbocysteine that promotes repair of the affected middle ear lining could be useful for the medical treatment of otitis media with effusion
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