Abstract
Effects of calcium hopantenate (HOPA) on the hypothalamic pituitary-thyroid axis in rats were studied. Basal plasma thyrotropin (TSH) levels significantly decreased from 277 +/- 24 to 167 +/- 24 ng/ml (p less than 0.01) at 20 min after HOPA administration. In the bicuculline-pretreated rats, the inhibitory effect of HOPA on TSH release was corrected. The plasma immunoreactive thyrotropin-releasing hormone (TRH) and TSH responses to cold were significantly inhibited after HOPA administration. The plasma TSH response to TRH was also significantly inhibited by HOPA. The plasma thyroxine and 3,3', 5-triiodothyronine levels did not change after HOPA administration. Findings suggest that HOPA acts both on the hypothalamus and pituitary gland, inhibiting TRH and TSH release.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
