Abstract
Anxiolytic-like activity of magnesium chloride has been exhibited in the elevated plus-maze test in mice, in several studies. Buspirone is an anxiolytic psychoactive drug of the azapirone chemical class that is not related to benzodiazepines, unlike most drugs predominately used. The purpose of the present study was to examine interaction between magnesium (Mg) and buspirone as a partial agonist of 5-HT1A receptors in producing anxiolytic-like activity in the elevated plus maze. The anxiolytic-like effect of Mg (50, 100 and 200 mg/kg, orally), buspirone (5 mg/kg, i.p) and its interaction with Mg (50 mg/kg) was evaluated after ten days treatment. Mg given at all doses (50, 100 and 200 mg/kg) and buspirone (5 mg/kg) induced an anxiolytic-like effect significantly increasing the percentage of the time spent in the open arms (%OAT), the percentage of the open arm entries (%OAE) and number of total entries. Percent time spend in open arms was reduced when buspirone coadministered with Mg (50 mg/kg) compared to Mg alone. However, the number of entries did not change significantly. No synergistic interaction (increased time in open arms and number of open arm entries) between Mg and buspirone was observed, in this test, on the contrary, %OAT preserved about buspirone effects and %OAE remained around Mg effect. The obtained data indicate that Mg may act partly via serotonergic receptors due to buspirone’s inhibitory action as a partial agonist of serotonin receptor.
Highlights
Anxiety disorders are a group of mental diseases characterized by excessive feelings of anxiety and fear, whereHow to cite this paper: Jahromy, M.H., Golbaghi, G., Mohajer, A.J., Poor, F.K. and Riazi, M. (2014) Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice
We investigated the interaction between Mg and commonly accepted anxyolitic drug, buspirone as a partial agonist of 5-HT1A receptors, in producing anxiolytic-like activity in the elevated plus maze in mice
In combination with Mg (50 g/kg), buspirone did not produce more effect compared to buspirone, in other words, the combination effect was lower than Mg 50 mg/kg, alone (Figure 1)
Summary
Anxiety disorders are a group of mental diseases characterized by excessive feelings of anxiety and fear, whereHow to cite this paper: Jahromy, M.H., Golbaghi, G., Mohajer, A.J., Poor, F.K. and Riazi, M. (2014) Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice. Anxiety disorders are a group of mental diseases characterized by excessive feelings of anxiety and fear, where. These feelings may cause physical symptoms such as a racing heart and shakiness [1]. Anxiety disorders are partly genetic but may be due to drug use including alcohol and caffeine. They often occur with other mental disorders. Common treatment options include lifestyle changes, therapy, and medications. Medications are typically recommended only if other measures are not effective [2]
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