Effects of Bushen-Yitai powder combined with progesterone on patients with early threatened abortion progesterone and β-HCG levels

Abstract

Objective To investigate the effects of Bushen-Yitai powder combined with progesterone on serum levels of progesterone and β-human chorionic gonadotropin (β-HCG) in patients with early threatened abortion. Methods A total of 96 patients with early threatened abortion were randomly divided into a control group and a treatment group by random number table method, with 48 patients in each group. The patients in the control group received injection of progesterone, 20 mg, 3/week. The patients in the treatment group were treated with Bushen-Yitai powder, 1 agent/d on the basis of the control group. Both groups were treated for 14 days. At the end of treatment, the serum levels of progesterone and β-HCG were detected, and the clinical efficacy was evaluated. Results The total effective rates in the treatment and control groups were 93.7% and 79.2%, respectively, with statistical difference (χ2=4.360, P=0.037). After the treatment, the serum levels of β-HCG (38.37 ± 5.66 ng/ml vs. 30.63 ± 3.86 ng/ml, t＝7.827) and progesterone (17 645.40 ± 2 483.11 U/L vs. 15 442.24 ± 1 633.16 U/L, t＝5.136) in the treatment group were significant higher than those in the control group. The scores of bleeding time (1.52 ± 0.31 vs. 2.01 ± 0.35, t=7.261), bleeding amount (1.41 ± 0.33 vs.1.89 ± 0.26, t=7.916), backache pain (1.33 ± 0.30 vs.1.98 ± 0.25, t=6.464), abdominal pain and distension (1.43 ± 0.33 vs.1.79 ± 0.20, t=11.532) in the treatment group were significant lower than those in the control group(P<0.01). Conclusion Bushen-Yitai powder adjuvant to progesterone therapy can improve the clinical outcome in patients with early threatened abortion. Key words: Abortion, threatened; Progesterone; Chorionic gonadotropin, β subunit, human; Bushen-Yitai powder