Effects of blood glucose on liver injury in hepatitis B virus infected patients

Abstract

Objective To investigate the effects of blood glucose on liver injury of HBV infected patients. Methods A total of 1364 biopsy-proven HBV infected patients were enrolled between July, 2005 and June, 2013. Those individuals were divided into either normal fasting plasma glucose (FPG)(n=1270)- and elevated FPG (n=94)- group according to their FPG level. Biochemical and pathological data were collected and compared between the two groups. Results The level of HBV DNA in normal FPG group was higher than that of elevated FPG group (t=3.25, P=0.00), but other biochemical indexes had no difference between the two groups (P>0.05 for all). Comparing with the normal FPG group, the elevated FPG group had higher steatosis, but there were no significant differences in inflammation and fibrosis stage between the two groups. Conclusion Elevated blood glucose could promote the incidence of steatosis in HBV infected patients. Key words: Hepatitis B, virus; Blood glucose; Liver diseases