Distribution of mean platelet volume in the healthy and impaired fasting glucose individuals

Abstract

Objective The different distribution and clinical significance of mean platelet volume (MPV) in the healthy normoglycemic and impaired fasting glucose (IFG) individuals were discussed. Methods The 499 individuals including 184 male and 315 female,who had undergone health checks in Tianjin Huanhu Hospital during May and July 2012 were studied retrospectively.Average age is forty-five (thirty-five to eighty).Subjects were categorized into four groups according to fasting plasma glucose （FPG） levels:G1 (3.89 mmol/L≤FPG＜5 mmol/L, n=125),G2(5 mmol/L≤FPG＜5.5 mmol/L, n=121), G3(5.5 mmol/L≤FPG＜6.1 mmol/L, n=142), and G4(6.1 mmol/L≤FPG＜7 mmol/L, n=111).G1, G2, and G3 are defined as normal FPG groups and G4 is defined as IFG group.Eighty-nine cases in the same age patients with type II diabetes mellitus group (G5) were observed at the same time. Results The MPV increased with the increasing FPG levels in the following order:G1(8.62±0.77) fl, G2 (8.85±0.80) fl, G3(8.90±0.69) fl,G4(9.14±0.78) fl and G5(12.03±1.42) fl.MPV［（12.03±1.42） fl］ of type Ⅱ diabetes mellitus group(G5) was higher than that in the IFG group(G4)［（9.14±0.78） fl］ and normal FPG groups［G1（8.62±0.77） fl,G2（8.85±0.80） fl,G3（8.90±0.69） fl］ (F=12.773,P＜0.01)；MPV of the IFG group［（9.14±0.78） fl］ was significantly higher than that in normal FPG groups［G1（8.62±0.77） fl,G2（8.85±0.80） fl,G3（8.90±0.69） fl］ (F=12.773,P＜0.01 for G4 vs. G1 and G2, P＜0.05 for G4 vs. G3) ；MPV in the high-normal glucose group (G3) ［（8.90±0.69） fl］ was obviously higher than that in the low-normal glucose group (G1) ［（8.62±0.77） fl］ (F=12.773,P＜0.05)；MPV was positively associated with FPG in normal FPG groups ,IFG group and type Ⅱ diabetes mellitus group (G1-3：r=0.22, P＜0.05；G4：r=0.26, P＜0.01；G5：r=0.29, P＜0.01). Conclusions Significant difference of MPV was observed in population of different FPG levels. Especially, MPV in IFG group was evidently higher than that in normal FPG group and was positively associated with FPG levels.（Chin J Lab Med,2014,37:451-454） Key words: Mean platelet volume; Blood glucose; Diabetes mellitus, type 2