Abstract
Objective To investigate the effects of blood glucose fluctuations on the function of islet beta cell in elderly patients with type 2 diabetes mellitus. Methods The clinical data of 108 elderly patients with type 2 diabetes mellitus treated in the Affiliated Hospital of Datong University from July 2016 to January 2018 were retrospectively analyzed. According to the average blood glucose fluctuation (MAGE), the 108 elderly patients were divided into MAGE abnormal group (MAGE ≥ 3.9 mmol/ L, 65 cases) and the MAGE normal group (MAGE <3.9 mmol/L, 43 cases). The levels of fasting insulin (FINS), postprandial 2 h blood glucose (2 h PG), postprandial 2 h C peptide (2 h C peptide), fasting C peptide, and homeostasis model insulin secretion index (HOMA-β) and homeostasis model insulin resistance index (HOME-IR) were compared between the two groups. Results There was no significant difference between the two groups in FINS, 2 h C peptide, fasting C peptide or HOME-IR value (P>0.05); the level of HOME-β in normal MAGE group was lower than that in abnormal MAGE group, and the level of 2 h PG was higher than that in abnormal MAGE group (P 1). Conclusions The fluctuation of blood glucose in elderly type 2 diabetes mellitus can lead to the attenuation of pancreatic islet beta cell function and the weakening of the body’s ability to regulate blood glucose, thus leading to the elevation of postprandial blood glucose levels. Key words: Elderly; Type 2 diabetes; Blood sugar fluctuation; Islet beta cell function
Published Version
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