Effects of Black Turmeric Ethanol Extract (Curcuma Caesia Roxb) on Blood Glucose Levels, SGOT, SGPT, Histopathology Pancreas: A Preliminary Study

Abstract

Diabetes mellitus (DM) is a condition that causes hyperglycemia and glucose intolerance. It can be caused by insulin deficiency, impaired insulin effectiveness, or both. Treatment of diabetes mellitus is long-term and certainly has unwanted side effects. The purpose of this study was to determine the effect of black turmeric extract on blood glucose, SGOT, SGPT values and pancreatic beta cell histopathology. This study used a Randomized Control Group Design on 30 white rats by giving a high-fat diet and induced streptozotocin 35 mg/kgbw intraperitoneally. Experimental animals were divided into 6 treatment groups, namely negative control, positive control, black turmeric extract doses of 250 mg/kgbw, 500 mg/kgbw, and 750 mg/kgbw. Assessment of the decrease in blood glucose levels is seen from the percentage of blood sugar reduction for 21 days, the value of SGOT, SGPT and histopathology of pancreatic beta cells. Data were analyzed using ANOVA test to see differences between groups. Based on the results obtained, that there is a significant difference in the administration of 750 mg/kgbw dose extract reduces blood sugar levels best by 57.71% compared to the negative control group where there is an increase in blood sugar by 9.94%. Based on the value of SGOT and SGPT levels, it was found that the 750 mg/kgbw dose of extract gave the best value compared to other treatment groups. Based on the parameters of the histopathological picture of pancreatic beta cells, it was found that the administration of black turmeric extract at a dose of 250 mg/kgbw experienced the mildest degeneration compared to other treatment groups. Ethanol extract of black turmeric (Curcuma caesia Roxb) is able to reduce blood sugar levels, SGOT, SGPT values and repair damage to pancreatic beta cells.