Abstract
Objective To test the role of a bioartificial kidney which consisted of a continuous vein-vein hemofiltration (CVVH) system and renal proximal tubule cells (PTCs) device, also called the renal tubule assist device (RAD), in endotoxin shock. Methods Female crossbred pigs 25 to 30 kg received with 3×10^11 bacteria/kg body weight of E. coli intraperitoneally followed by treatment with a sham RAD without cells (n=7) or a RAD with cells (n=7). Data on blood pressure, cardiac output, renal blood flow and systemic marker of inflammation (IL-6) were measured. Results Cardiac outputs and renal blood flows were higher in the RAD group with cells than in the sham RAD group after E. coli infusion (P＜0.05). Plasma IL-6 levels were lower in the cell RAD group than in the sham RAD group after bacterial administration (P＜0.05). A significant difference on survival time was also observed between the two groups, with (9.07±0.88) h in the cell RAD group vs. (5.10±0.46) h in the sham RAD group, P＜0.01. Conclusion The bioartificial kidney containing PTCs can improve cardiovascular function, reduce cytokine levels, and prolong survival time.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
