Abstract
Abstract Background: To investigate the effects of bile duct stricture on the pharmacokinetics of the immunosuppressant tacrolimus, the pharmacokinetics of tacrolimus in rats with bile duct ligation were evaluated and
Highlights
IntroductionTacrolimus (TAC), an immunosuppressive agent (molecular weight of the non-hydrate form, 806), inhibits the signal transduction pathway involved in the activation of T-lymphocytes [1,2]
Tacrolimus (TAC), an immunosuppressive agent, inhibits the signal transduction pathway involved in the activation of T-lymphocytes [1,2]
The levels of GPT, glutamic oxaloacetic transaminase (GOT), and alkaline phosphatase (ALP) were significantly higher in BDL rats than in control rats
Summary
Tacrolimus (TAC), an immunosuppressive agent (molecular weight of the non-hydrate form, 806), inhibits the signal transduction pathway involved in the activation of T-lymphocytes [1,2]. TAC is used for preventing or treating graft rejection after organ transplantation [3], and is superior to cyclosporine (CyA) in improving survival (patient and graft) and preventing acute rejection in living donor liver transplantation patients [4]. TAC is the drug of choice for living donor liver transplant recipients in our university hospital, Kyoto Prefectural University of Medicine. TAC is highly lipophilic and insoluble in water, and is a substrate for the drug efflux pump, P-glycoprotein (Pgp), and the metabolizing enzyme, cytochrome P450 (CYP) 3A. These physicochemical properties of TAC contribute to the large variation in oral absorption and extensive metabolic clearance from the body. To investigate the effects of bile duct stricture on the pharmacokinetics of the immunosuppressant tacrolimus, the pharmacokinetics of tacrolimus in rats with bile duct ligation were evaluated and the effects of the amount of intestinal bile on intestinal tacrolimus absorption were determined
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
