Effects of beta-amyloid on cholinergic, cholinoceptive and GABAergic neurons

Abstract

Alzheimer’s disease is primarily characterized by neurofibrillary tangles, senile plaques and a cholinergic hypofunction. In this study, the morphological signs of toxicity of amyloid β (Aβ) 1–42 and short amyloid peptide fragments corresponding to amino acids 31–35 and 34–39 were investigated on cholinergic, cholinoceptive and GABAergic neuronal populations of basal forebrain cultures.