Effects of benzodiazepine receptor agonists on cognitive function in patients with chronic insomnia

Abstract

AbstractBackgroundTo investigate the effects of benzodiazepine receptor agonists on cognitive function in patients with chronic insomnia.MethodAccording to the history of taking hypnotic drugs, they were divided into no medication group (n = 62), benzodiazepines group (n = 57) and non‐benzodiazepines group (n = 53); all subjects The Pittsburgh Sleep Quality Scale, the Epworth Scale, and the Insomnia Severity Index were used to evaluate their sleep quality, and the Hamilton Anxiety and Depression Scale to evaluate their anxiety and depression. The conversion test, the auditory word learning test was used to evaluate the memory function, and the Stroop color word test and the connection function test were used to evaluate the executive function.ResultCompared with no medication, the non‐benzodiazepine group and the benzodiazepine group had longer sleep time throughout the night (P<0.05), and the non‐benzodiazepine group and the benzodiazepine group. The anxiety and depression scores of the drug group were lower than those of the non‐drug group (P<0.05), and the immediate memory and delayed memory scores of the benzodiazepine group and the non‐drug group were lower than those of the non‐benzodiazepine group (P<0.05). 0.05), the dose and duration of medication in the benzodiazepine group were negatively correlated with immediate memory (P<0.05), and the duration of medication in the benzodiazepine group was negatively correlated with prolonged memory (P<0.05). Regression analysis showed that the immediate memory score of taking benzodiazepines was 2.612 times lower than that of the non‐drug group, and the delayed memory score of taking non‐benzodiazepines was 1.439 times higher Regression analysis showed that the immediate memory score of taking benzodiazepines was 2.612 times lower than that of the non‐drug group, and the delayed memory score of taking non‐benzodiazepines was 1.439 times higher than that of the non‐drug group (P<0.05). The difference is statistically significant.ConclusionBenzodiazepines increase the risk of impaired immediate memory function in patients with chronic insomnia, and non‐benzodiazepines can improve their delayed memory function.