Effects of BCG polysaccharide nucleotides combined with Tripterygium wilfordii polyglycosides on inflammatory factors and T cell subsets in patients with chronic urticaria

Abstract

Objective To study the effect of BCG polysaccharide nucleic acid combined with Tripterygium wilfordii polyglycoside(TWP) on inflammatory factors and T cell subsets in patients with chronic urticaria. Methods From January 2015 to January 2017, 84 patients of chronic urticaria in Gujiao Central Hospital were selected in the research.The patients were randomly divided into observation group and control group, with 42 cases in each group.The control group was treated with conventional therapy, and the observation group was treated with BCG polysaccharide nucleic acid combined with TWP.The levels of IL-2, IL-4, IL-10, peripheral blood interferon-γ(IFN-γ), T cell subsets(CD4+ , CD8+ , CD4+ /CD8+ ) were observed, and the clinical efficacy was compared. Results After treatment, the total effective rate of the observation group was higher than that of the control group[41(97.62%) vs.36(85.71%)](χ2=3.896, P<0.05). The levels of IL-2 and IFN-γ in the observation group were higher than those in the control group[(314.54±45.47)ng/L vs.(285.04±46.84)ng/L, (310.25±32.80)ng/L vs.(265.14±28.11)ng/L](t=2.928, 6.767, all P<0.05). The levels of IL-4 and IL-10 in the observation group were lower than those in the control group[(18.65±3.14)ng/L vs.(26.09±4.52)ng/L, (57.65±6.34)ng/L vs.(63.74±6.82)ng/L](t=8.760, 4.238, all P<0.05). The levels of CD4+ , CD4+ /CD8+ in the observation group were higher than those in the control group[(39.86±6.96)% vs.(34.44±7.06)%, (1.60±0.14) vs.(1.34±0.15)](t=3.543, 8.212, all P<0.05). The level of CD8+ in the observation group was lower than that in the control group[(24.34±3.99)% vs.(27.24±4.33)%](t=3.191, P<0.05). Conclusion BCG polysaccharide nucleic acid combined with TWP in the treatment of chronic urticaria can effectively increase peripheral blood IFN-γ and IL-2 levels, decrease IL-4, IL-10 levels, improve levels of inflammatory cytokines and T cell subsets(CD4+ , CD8+ and CD4+ /CD8+ ), the efficacy is safe and reliable, it is worthy of application and promotion. Key words: BCG polysaccharide nucleic acid; Tripterygium wilfordii polyglycoside; Drug therapy, combination; Urticaria; Inflammatory factor; Interleukins; Interferon-gamma; T cell subsets